Fosinopril

In the US, Fosinopril (fosinopril systemic) is a member of the drug class angiotensin converting enzyme inhibitors and is used to treat Diabetic Kidney Disease, High Blood Pressure and Left Ventricular Dysfunction.

US matches:

• Fosinopril


• Fosinopril/Hydrochlorothiazide


• Fosinopril and hydrochlorothiazide


• Fosinopril Sodium

UK matches:

• Fosinopril Tablets 10mg, 20mg (Actavis UK Ltd)
• Fosinopril Sodium 20mg Tablets (SPC)

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

C09AA09

CAS registry number (Chemical Abstracts Service)

0098048-97-6

Chemical Formula

C30-H46-N-O7-P

Molecular Weight

563

Therapeutic Category

ACE inhibitor

Chemical Name

L-Proline, 4-cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy)propoxy](4-phenylbutyl)-phosphinyl]acetyl]-, trans-

Foreign Names

• Fosinoprilum (Latin)
• Fosinopril (German)
• Fosinopril (French)
• Fosinopril (Spanish)

Generic Names

• Fosinopril (OS: BAN)
• Fosenopril (IS)
• Fosinopril Sodium (OS: USAN, BANM)
• SQ 28555 (IS: Squibb)
• Fosinopril sodium (PH: USP 32)

Brand Names

• Fosace
  Merck, Slovenia



• Fosicard Plus (Fosinopril and Hydrochlorothiazide)
  Actavis, Bulgaria; Balkanpharma, Bulgaria



• Fosicard
  Actavis, Russian Federation



• Fosinopril Arrowblue
  Arrowblue, Portugal



• Fosinopril Generis
  Generis, Portugal



• Fosiran
  Ranbaxy, Romania



• Fositen
  Bristol-Myers Squibb, Portugal



• Fosypril
  Terapia, Romania



• Fozinopril
  Arrow, Slovenia



• Fozitec
  Merck Serono, France



• Monopril
  Aventis, Peru; Bristol-Myers Squibb, Colombia; Bristol-Myers Squibb, Iceland; Bristol-Myers Squibb, Romania; Jadran, Bosnia & Herzegowina



• Tevafos (Fosinopril and Hydrochlorothiazide)
  Teva, Slovakia



• Acenor-M
  Bristol-Myers Squibb, Indonesia



• Apo-Fosinopril
  Apotex, Canada



• Bpnorm
  Westmont, Philippines



• DiurAce (Fosinopril and Hydrochlorothiazide)
  Bristol-Myers Squibb, Netherlands



• Doc Fosinopril
  Docpharma, Luxembourg



• Duopril (Fosinopril and Hydrochlorothiazide)
  Bristol-Myers Squibb, Hungary



• Dynacil
  Sanol, Germany; Schwarz, Germany



• Dynacil comp (Fosinopril and Hydrochlorothiazide)
  Sanol, Germany; Schwarz, Germany



• Eliten
  Bristol-Myers Squibb, Italy



• Fosicard Plus (Fosinopril and Hydrochlorothiazide)
  Actavis, Hungary



• Fosicard
  Actavis, Bulgaria; Balkanpharma, Bulgaria



• Fosicomb (Fosinopril and Hydrochlorothiazide)
  Bristol-Myers Squibb, Austria



• Fosicombi (Fosinopril and Hydrochlorothiazide)
  Menarini, Italy



• Fosicomp (Fosinopril and Hydrochlorothiazide)
  Bristol-Myers Squibb, Switzerland



• Fosinil
  Bristol-Myers Squibb, Belgium; Bristol-Myers Squibb, Luxembourg



• Fosinogen
  Generics, Slovakia



• Fosinopril Actavis
  Actavis, Estonia; Actavis, France; Actavis, Lithuania; Actavis, Latvia; Actavis, Malta; Actavis, Sweden



• Fosinopril Arrow
  Arrow, France



• Fosinopril Basics
  Basics, Germany



• Fosinopril Biogaran
  Biogaran, France



• Fosinopril CristerS
  CristerS, France



• Fosinopril EG
  EG Labo, France



• Fosinopril HCT Actavis (Fosinopril and Hydrochlorothiazide)
  Actavis, Switzerland



• Fosinopril HCT Sandoz (Fosinopril and Hydrochlorothiazide)
  Sandoz, Australia



• Fosinopril HCT Winthrop (Fosinopril and Hydrochlorothiazide)
  Sanofi-Aventis, Australia



• Fosinopril Hydrochlorothiazide Actavis (Fosinopril and Hydrochlorothiazide)
  Actavis, France



• Fosinopril Hydrochlorothiazide Biogaran (Fosinopril and Hydrochlorothiazide)
  Biogaran, France



• Fosinopril Hydrochlorothiazide EG (Fosinopril and Hydrochlorothiazide)
  EG Labo, France



• Fosinopril Hydrochlorothiazide Mylan (Fosinopril and Hydrochlorothiazide)
  Mylan, France



• Fosinopril Hydrochlorothiazide Ranbaxy (Fosinopril and Hydrochlorothiazide)
  Ranbaxy, Spain



• Fosinopril Hydrochlorothiazide Teva (Fosinopril and Hydrochlorothiazide)
  Teva, Spain; Teva Santé, France



• Fosinopril Hydrochlorothiazide Winthrop (Fosinopril and Hydrochlorothiazide)
  Sanofi-Aventis, France



• Fosinopril Interpharm
  Interpharm, Austria



• Fosinopril Merck
  Merck Genericos, Spain



• Fosinopril Mylan
  Mylan, France



• Fosinopril Na A
  Apothecon, Netherlands



• Fosinopril Qualimed
  Qualimed, France



• Fosinopril Ranbaxy
  Ranbaxy, Spain



• Fosinopril Sandoz
  Sandoz, Australia



• Fosinopril Sodium and Hydrochlorothiazide (Fosinopril and Hydrochlorothiazide)
  Andrx, United States; Aurobindo, United States; InvaGen, United States; Mylan, United States; Ranbaxy, United States; Sandoz, United States; Watson, United States



• Fosinopril Sodium
  Apotex, United States; Cobalt, United States; InvaGen, United States; Ranbaxy, United States; Sandoz, United States; Teva USA, United States; Watson, United States



• Fosinopril Teva
  Pharmachemie, Bulgaria; Teva, Bulgaria; Teva, Spain; Teva, Lithuania; Teva, Slovakia; Teva Santé, France



• Fosinopril Winthrop
  Sanofi-Aventis, Australia; Sanofi-Aventis, France; Winthrop, Portugal; Winthrop, Slovakia



• Fosinopril/HCT Interpharm (Fosinopril and Hydrochlorothiazide)
  Interpharm, Austria



• Fosinopril/HCT Stada (Fosinopril and Hydrochlorothiazide)
  Stada, Austria



• Fosinopril/Hydrochlorothiazide CristerS (Fosinopril and Hydrochlorothiazide)
  CristerS, France



• Fosinopril+pharma
  +pharma, Slovakia



• Fosinopril-Actavis comp (Fosinopril and Hydrochlorothiazide)
  Actavis, Germany



• Fosinoprilnatrium Actavis
  Actavis, Netherlands



• Fosinoprilnatrium Apotex
  Apotex Europe, Netherlands



• Fosinoprilnatrium Arrow
  Arrow, Netherlands



• Fosinoprilnatrium CF
  Centrafarm, Netherlands



• Fosinoprilnatrium Copyfarm
  Copyfarm, Netherlands



• Fosinoprilnatrium Katwijk
  Apotex Europe, Netherlands



• Fosinoprilnatrium Merck
  Mylan, Netherlands



• Fosinoprilnatrium PCH
  Pharmachemie, Netherlands



• Fosinoprilnatrium ratiopharm
  ratiopharm, Netherlands



• Fosinoprilnatrium Sandoz
  Sandoz, Netherlands



• Fosinoprilnatrium Teva
  Teva, Denmark



• Fosinopril-Natrium/HCT Actavis (Fosinopril and Hydrochlorothiazide)
  Actavis, Austria



• Fosinopril-Ranbaxy
  Basics, Germany



• Fosinopril-Teva
  Teva, Czech Republic



• Fosinorm
  Bristol-Myers Squibb, Germany



• Fosinorm comp (Fosinopril and Hydrochlorothiazide)
  Bristol-Myers Squibb, Germany



• Fosino-Teva
  Teva, Germany



• Fosipres
  Menarini, Italy



• Fosipril
  Sigma, Australia



• Fositen
  Bristol-Myers Squibb, Switzerland



• Fositens Plus (Fosinopril and Hydrochlorothiazide)
  Bristol-Myers Squibb, Spain



• Fositens
  Bristol-Myers Squibb, Austria; Bristol-Myers Squibb, Spain



• Fovas
  Cadila, India



• Fozide (Fosinopril and Hydrochlorothiazide)
  Bristol-Myers Squibb, Greece



• Foziretic (Fosinopril and Hydrochlorothiazide)
  Merck Serono, France



• Gen-Fosinopril
  Genpharm, Canada



• GenRX Fosinopril
  Apotex, Australia



• Hiperlex Plus (Fosinopril and Hydrochlorothiazide)
  Bristol-Myers Squibb, Spain



• Hiperlex
  Bristol-Myers Squibb, Spain



• Merck-Fosinopril
  Xixia, South Africa



• Monace
  Alphapharm, Australia



• Monoplus (Fosinopril and Hydrochlorothiazide)
  Bristol-Myers Squibb, Australia



• Monopril HCT (Fosinopril and Hydrochlorothiazide)
  Bristol-Myers Squibb, United States



• Monopril
  Bristol Meyers Squibb, Latvia; Bristol-Myers Squibb, Australia; Bristol-Myers Squibb, Brazil; Bristol-Myers Squibb, Canada; Bristol-Myers Squibb, Chile; Bristol-Myers Squibb, China; Bristol-Myers Squibb, Czech Republic; Bristol-Myers Squibb, Estonia; Bristol-Myers Squibb, Georgia; Bristol-Myers Squibb, Greece; Bristol-Myers Squibb, Hong Kong; Bristol-Myers Squibb, Hungary; Bristol-Myers Squibb, Lithuania; Bristol-Myers Squibb, Poland; Bristol-Myers Squibb, Serbia; Bristol-Myers Squibb, Russian Federation; Bristol-Myers Squibb, Singapore; Bristol-Myers Squibb, Slovakia; Bristol-Myers Squibb, Turkey; Bristol-Myers Squibb, Taiwan; Bristol-Myers Squibb, United States; Bristol-Myers Squibb, Venezuela; Bristol-Myers Squibb, South Africa; Jadran, Croatia (Hrvatska); PharmaSwiss, Slovenia



• Monopril (Fosinopril and Hydrochlorothiazide)
  Jadran, Croatia (Hrvatska)



• Monozide (Fosinopril and Hydrochlorothiazide)
  Bristol-Myers Squibb, Slovakia; Bristol-Myers Squibb, South Africa



• Newace
  Bristol-Myers Squibb, Netherlands



• Noviform
  Teva, Hungary



• Novo-Fosinopril
  Novopharm, Canada



• Staril
  Bristol-Myers Squibb, United Kingdom; Bristol-Myers Squibb, Oman



• Tenso Stop Plus (Fosinopril and Hydrochlorothiazide)
  Laboratorios Dr Esteve, Spain



• Tenso Stop
  Laboratorios Dr Esteve, Spain



• Tensocardil
  Laboratorios Dr Esteve, Spain



• Tensogard
  Bristol-Myers Squibb, Italy

International Drug Name Search

Glossary

BAN	British Approved Name
BANM	British Approved Name (Modified)
IS	Inofficial Synonym
OS	Official Synonym
PH	Pharmacopoeia Name
Rec.INN	Recommended International Nonproprietary Name (World Health Organization)
SPC	Summary of Product Characteristics (UK)
USAN	United States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Selenium Drench

Selenium Drench may be available in the countries listed below.

In some countries, this medicine may only be approved for veterinary use.

Ingredient matches for Selenium Drench

Selenium

Selenium is reported as an ingredient of Selenium Drench in the following countries:

• New Zealand

International Drug Name Search

Dimetikon Meda

Dimetikon Meda may be available in the countries listed below.

Ingredient matches for Dimetikon Meda

Simeticone

Simeticone is reported as an ingredient of Dimetikon Meda in the following countries:

• Sweden

International Drug Name Search

Rapaflo

Generic Name: Silodosin
Class: Selective alpha-1-Adrenergic Blocking Agents
ATC Class: G04CA04
VA Class: GU900
Chemical Name: 1 - (3 - hydroxypropyl) - 5 - [(2R) - 2 - [[2 - [2 - (2,2,2 - trifluoroethoxy)phenoxy]ethyl]amino]propyl] - 2,3 - dihydro - 1H - indole - 7 - carboxamide
Molecular Formula: C₂₅H₃₂F₃N₃O₄
CAS Number: 160970-54-7

Introduction

α₁-Adrenergic blocker with selectivity for α_1A-adrenergic receptors;¹ trifluoroethoxy-phenoxyethyl amine derivative.¹⁰

Uses for Rapaflo

Benign Prostatic Hyperplasia (BPH)

Reduction of urinary obstruction and relief of associated manifestations (e.g., hesitancy, weak stream, sensation of incomplete bladder emptying, frequency, urgency, nocturia) in patients with symptomatic BPH.^{1 3 4 5 6}

May be a useful alternative to surgery, particularly in those who are awaiting surgical correction of hyperplasia or who are not candidates for such surgery.^{3 5}

May consider combined therapy with an α_1A-adrenergic blocking agent and a 5α-reductase inhibitor for men with bothersome moderate to severe BPH.^{8 9} Has been more effective than therapy with either drug alone in preventing long-term BPH symptom progression.^{8 9} Men at risk for BPH progression are most likely to benefit from combination therapy.⁸

Other Uses

Manufacturer states that silodosin should not be used for the treatment of hypertension.¹

Rapaflo Dosage and Administration

Administration

Oral Administration

Administer orally once daily with a meal.^{1 4}

Dosage

Adults

BPH

Oral

8 mg once daily.^{1 4}

Special Populations

Hepatic Impairment

Dosage adjustment not necessary in patients with mild or moderate hepatic impairment (Child-Pugh class A or B).¹ Not recommended for use in patients with severe hepatic impairment (Child-Pugh class C).^{1 7}

Renal Impairment

Dosage adjustment not necessary in patients with mild renal impairment (Cl_cr 50–80 mL/minute).¹ Reduce dosage to 4 mg once daily in patients with moderate renal impairment (Cl_cr 30–50 mL/minute).^{1 7} Not recommended for use in patients with severe renal impairment (Cl_cr <30 mL/minute).^{1 7}

Cautions for Rapaflo

Contraindications

• 
  

  Severe hepatic impairment (Child-Pugh class C).^{1 7}

  
  


• 
  

  Severe renal impairment (Cl_cr <30 mL/minute).^{1 7}

  
  


• 
  

  Concomitant use with potent inhibitors of CYP3A4 (e.g., clarithromycin, itraconazole, ketoconazole, ritonavir).^{1 7} (See Interactions.)

  
  

Warnings/Precautions

Warnings

Orthostatic Hypotension

Potential for orthostatic hypotension, dizziness, or syncope.¹ (See Advice to Patients.)

General Precautions

Prostate Cancer

Exclude possibility of prostate cancer prior to initiation of therapy.¹

Intraoperative Floppy Iris Syndrome

Intraoperative floppy iris syndrome (IFIS) observed during phacoemulsification cataract surgery in some patients currently receiving or previously treated with α₁-adrenergic blocking agents.^{1 3 7 8 11}

Specifically question male patients being considered for cataract surgery to determine whether they have received silodosin or other α₁-adrenergic blockers.^{1 11} If patient has received α₁-adrenergic blockers, ophthalmologist should consider modification of the surgical technique through use of iris hooks or iris dilator rings or pharmacologic intervention with intracameral phenylephrine or preoperative administration of atropine to minimize complications of IFIS.¹¹ Benefit of discontinuing α₁-blocker therapy prior to cataract surgery not established.^{8 11}

Specific Populations

Pregnancy

Category B.¹ Not indicated for use in women.¹

Lactation

Not indicated for use in women.¹

Pediatric Use

Not indicated for use in children.¹

Geriatric Use

Higher incidence of orthostatic hypotension reported in patients ≥65 years of age compared with younger adults.¹ No other substantial differences in safety and efficacy relative to younger adults.¹

Hepatic Impairment

Use not recommended in patients with severe hepatic impairment.^{1 7} (See Contraindications under Cautions.)

Renal Impairment

Use not recommended in patients with severe renal impairment.^{1 7} Use caution and reduce dosage in patients with moderate renal impairment.^{1 7}

Common Adverse Effects

Retrograde ejaculation, dizziness, diarrhea, orthostatic hypotension, headache, nasopharyngitis, nasal congestion.^{1 4 7}

Interactions for Rapaflo

Extensively metabolized by CYP3A4 and UGT2B7.^{1 7}

Drugs Affecting Hepatic Microsomal Enzymes

Pharmacokinetic interaction (increased plasma silodosin concentrations) with potent inhibitors of CYP3A4.¹ Concomitant use contraindicated.^{1 7}

Drugs Affecting or Affected by P-glycoprotein Transport

Silodosin is a substrate for the P-glycoprotein transport system.¹ Potential pharmacokinetic interaction (increased plasma silodosin concentrations) with inhibitors of P-glycoprotein transport.^{1 7} Concomitant use with a potent P-glycoprotein inhibitor not recommended.^{1 7}

Drugs Affecting Uridine Diphosphate-glucuronosyltransferase (UGT) 2B7

Potential pharmacokinetic interaction (increased silodosin exposure) with inhibitors of UGT2B7.¹

Specific Drugs

Drug	Interaction	Comments
α-Adrenergic blocking agents	Possible pharmacodynamic interaction1	Concomitant use not recommended1
Antihypertensive agents	Higher incidence of dizziness and orthostatic hypotension1	Use with caution;1 monitor for adverse effects1
Clarithromycin	Increased plasma silodosin concentrations1	Concomitant use contraindicated1
Cyclosporine	Potential for increased plasma silodosin concentrations1	Concomitant use not recommended1
Digoxin	No substantial change in digoxin pharmacokinetics1	Dosage adjustment not required1
Diltiazem	Potential for increased plasma silodosin concentrations1	Use with caution;1 monitor for adverse effects1
Erythromycin	Potential for increased plasma silodosin concentrations1	Use with caution;1 monitor for adverse effects1
Fluconazole	Potential for increased silodosin exposure1
Itraconazole	Increased plasma silodosin concentrations1	Concomitant use contraindicated1
Ketoconazole	Substantially increased plasma silodosin concentrations and silodosin exposure1	Concomitant use contraindicated1
Phosphodiesterase (PDE) type 5 inhibitors (e.g., sildenafil, tadalafil)	Possible orthostatic effects7
Probenecid	Potential for increased silodosin exposure1
Ritonavir	Increased plasma silodosin concentrations1	Concomitant use contraindicated1
Valproic acid	Potential for increased silodosin exposure1
Verapamil	Potential for increased plasma silodosin concentrations1	Use with caution;1 monitor for adverse effects1

Rapaflo Pharmacokinetics

Absorption

Bioavailability

Absolute bioavailability of approximately 32% following oral administration under fed conditions.¹ Peak plasma concentrations attained in about 2.6 hours.¹

Food

When administered with a moderate-fat, moderate-calorie meal, AUC and peak plasma concentrations are decreased by 4–49% and 18–43%, respectively, compared with administration in the fasting state.¹ Administration with a high-fat, high-calorie meal not evaluated.¹

Distribution

Plasma Protein Binding

Approximately 97%.¹

Elimination

Metabolism

Extensively metabolized in the liver via glucuronidation, alcohol and aldehyde dehydrogenases, and CYP3A4 isoenzymes.¹ The primary active metabolite, KMD-3213G, is formed via UGT2B7-mediated glucuronidation.¹ Another major metabolite, KMD-3293, is formed via alcohol and aldehyde dehydrogenases.¹ KMD-3293 is not expected to contribute substantially to the overall pharmacologic activity of silodosin.¹

Elimination Route

Excreted in urine (33.5%) and feces (54.9%).¹

Half-life

Approximately 13.3 hours.¹

Special Populations

In patients with moderate hepatic impairment, the pharmacokinetics of silodosin were not substantially altered following administration of a single dose.¹ The pharmacokinetics of silodosin in patients with severe hepatic impairment have not been evaluated.¹

In patients with moderate renal impairment, AUC, peak plasma concentrations, and elimination half-life were 3.2, 3.1, and 2 times higher, respectively, than in healthy individuals.¹

In geriatric individuals, AUC and elimination half-life were increased by approximately 15% and 20%, respectively, compared with younger individuals.¹

Stability

Storage

Oral

Capsules

25°C (may be exposed to 15–30°C).¹ Protect from moisture and light.¹

ActionsActions

• 
  

  Blocks α₁-adrenergic receptors in the lower urinary tract to cause relaxation of smooth muscle in the bladder neck and prostate,^{1 2 3 4 5 7} resulting in improved urinary flow and reduced symptoms of BPH.^{1 3 5}

  
  


• 
  

  Higher affinity for α_1A-adrenergic receptors, which are in nonvascular smooth muscle (e.g., prostate), than for α_1B-adrenergic receptors located in vascular smooth muscle;^{1 2 3 5} may result in reduced incidence of cardiovascular effects (e.g., syncope, dizziness, hypotension).^{3 4 5}

  
  

Advice to Patients

• 
  

  Risk of orthostatic hypotension (e.g., feeling faint or dizzy), particularly following initiation of therapy;¹ importance of exercising caution when driving, operating machinery, or performing hazardous tasks.¹

  
  


• 
  

  Importance of taking silodosin once daily with a meal.¹

  
  


• 
  

  Risk of retrograde ejaculation.¹ Importance of advising patients that this adverse effect occurs frequently and is reversible upon discontinuance of therapy.¹

  
  


• 
  

  Importance of advising male patients being considered for cataract surgery that they should inform their ophthalmologist of current or prior α₁-blocker (e.g., silodosin) therapy.¹

  
  


• 
  

  Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.¹

  
  


• 
  

  Importance of informing patients of other important precautionary information.¹ (See Cautions.)

  
  

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Silodosin

Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Oral	Capsules	4 mg	Rapaflo	Watson
		8 mg	Rapaflo	Watson

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Rapaflo 8MG Capsules (WATSON LABS): 30/$125 or 90/$345.98

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions December 2009. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

1. Watson Pharma. Rapaflo (silodosin) capsules prescribing information. Corona, CA; 2008 Oct.

2. Anon. KMD 3213: KAD 3213, Silodosin. Drugs R D. 2004; 5:50-1.

3. Yoshida M, Homma Y, Kawabe K. Silodosin, a novel selective alpha 1A-adrenoceptor selective antagonist for the treatment of benign prostatic hyperplasia. Expert Opin Investig Drugs. 2007; 16:1955-65. [PubMed 18042003]

4. Marks LS, Gittelman MC, Hill LA et al. Rapid efficacy of the highly selective alpha1A-adrenoceptor antagonist silodosin in men with signs and symptoms of benign prostatic hyperplasia: pooled results of 2 phase 3 studies. J Urol. 2009; 181:2634-40. [PubMed 19371887]

5. Kawabe K, Yoshida M, Homma Y et al. Silodosin, a new alpha1A-adrenoceptor-selective antagonist for treating benign prostatic hyperplasia: results of a phase III randomized, placebo-controlled, double-blind study in Japanese men. BJU Int. 2006; 98:1019-24. [PubMed 16945121]

6. Takao T, Tsujimura A, Kiuchi H et al. Early efficacy of silodosin in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Int J Urol. 2008; 15:992-6. [PubMed 18775032]

7. Anon. Silodosin (Rapaflo) for benign prostatic hyperplasia. Med Lett Drugs Ther. 2009; 51:3-4.

8. American Urological Association. Guideline on the management of benign prostatic hyperplasia (BPH) (2003/updated 2006). Available from website. Accessed 2009 Aug 13.

9. Madersbacher S, Alivizatos G, Nordling J et al. EAU 2004 guidelines on assessment, therapy and follow-up of men with lower urinary tract symptoms suggestive of benign prostatic obstruction (BPH guidelines). Eur Urol. 2004; 46:547-54. [PubMed 15474261]

10. Watson Pharmaceuticals. Morristown, NJ: Personal communication.

11. Cantrell MA, Bream-Rouwenhorst HR, Steffensmeier A et al. Intraoperative floppy iris syndrome associated with alpha1-adrenergic receptor antagonists. Ann Pharmacother. 2008; 42:558-63. [PubMed 18364408]

More Rapaflo resources

• Rapaflo Side Effects (in more detail)
• Rapaflo Use in Pregnancy & Breastfeeding
• Drug Images
• Rapaflo Drug Interactions
• Rapaflo Support Group
• 29 Reviews for Rapaflo - Add your own review/rating

• Rapaflo Prescribing Information (FDA)


• Rapaflo Consumer Overview


• Rapaflo Advanced Consumer (Micromedex) - Includes Dosage Information


• Rapaflo MedFacts Consumer Leaflet (Wolters Kluwer)


• Silodosin Professional Patient Advice (Wolters Kluwer)

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Flutamide is reported as an ingredient of Flutamida Cinfa in the following countries:

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Tenoxicam is reported as an ingredient of Velasor in the following countries:

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Papain Marching may be available in the countries listed below.

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Papain is reported as an ingredient of Papain Marching in the following countries:

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Ingredient matches for Fluconazol MK

Fluconazole

Fluconazole is reported as an ingredient of Fluconazol MK in the following countries:

• Belize


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• Costa Rica


• Ecuador


• El Salvador


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International Drug Name Search

Carduran

In the US, Carduran is a member of the drug class antiadrenergic agents, peripherally acting and is used to treat Benign Prostatic Hyperplasia, High Blood Pressure and Raynaud's Syndrome.

Ingredient matches for Carduran

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Doxazosin mesilate (a derivative of Doxazosin) is reported as an ingredient of Carduran in the following countries:

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• Spain


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International Drug Name Search